発表論文

●TQT
  • Evaluation of Assay Sensitivity and the Concentration-Effect Relationship of Moxifloxacin in a QT/QTc Study in Japan
    Masanari Shiramoto, Hinako Uchimaru, Yoshikazu Kaji, Kyoko Matsuguma, Shunji Matsuki, Ippei Ikushima, Makoto Yonou and Shin Irie
    Therapeutic Innovation& Regulatory Science 2014, Vol. 48(2) 181-189
●マイクロドーズ試験
  • Pharmacokinetic and pharmacogenomic profiles of telmisartan after the oral microdose and therapeutic dose.
    Ieiri I, Nishimura C, Maeda K, Sasaki T, Kimura M, Chiyoda T, Hirota T, Irie S, Shimizu H, Noguchi T, Yoshida K, Sugiyama Y.
    Pharmacogenet Genomics 21(8): 495-505 (2011)
  • Microdosing clinical study: pharmacokinetic, pharmacogenomic (SLCO2B1), and interaction (grapefruit juice) profiles of celiprolol following the oral microdose and therapeutic dose.
    Ieiri I, Doi Y, Maeda K, Sasaki T, Kimura M, Hirota T, Chiyoda T, Miyagawa M, Irie S, Iwasaki K, Sugiyama Y.
    J Clin Pharmacol 52(7): 1078-89 (2012)
  • Microdose Study of 14C-Acetaminophen with accelerator mass spectrometry to examine pharmacokinetics of parent drug metabolites in healthy subjects.
    Tozuka Z, Kusuhara H, Nozawa K, Hamabe Y, Ikushima I, Ikeda T and Sugiyama Y.
    Clin Pharmacol Ther 88: 824-830 (2010).
  • Pharmacogenomic/pharmacokinetic assessment of a four-probe cocktail for CYPs and OATPs following oral microdosing.
    Ieiri I, Fukae M, Maeda K, Ando Y, Kimura M, Hirota T, Nakamura T, Iwasaki K, Matsuki S, Matsuguma K, Kanda E, Deguchi M, Irie S, Sugiyama Y.
    Int. J Clin Pharmacol Ther 50: 689-700 (2012)
  • Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam(CYP3A4), fexofenadine (p-glycoprotein), and pravastatin (OATP1B1) as probe drugs.
    Ieiri I, Tsunemitsu S, Maeda K, Ando Y, Izumi N, Kimura M, Yamane N, Okuzono T, Morishita M, Kotani N, Kanda E, Deguchi M, Matsuguma K, Matsuki S, Hirota T, Irie S, Kusuhara H, Sugiyama Y.
    J Clin Pharmacol 53(6): 654-6 (2013)
●薬物相互作用試験
  • Stereoselective 4’-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese」
    I. Ieiri, K. Mamiya, A. Urae, Y. Wada, M. Kimura, S. Irie, T. Amamoto, T. Kubota, S. Yoshioka, K. Nakamura, S. Nakano, N. Tashiro & S. Higuchi
    Br J Clin Pharmacol 1997;43:441-445
  • Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism」
    Suttasinee Suwannakul, Ichiro Ieiri, Miyuki Kimura, Kiyoshi Kawabata, Hiroyuki Kusuhara, Takeshi Hirota, Shin Irie, Yuichi Sugiyama, Shun Higuchi
    J Hum Genet (2008) 53: 899-904
  • 日本人健康成人男性志願者を対象としたアプレピタント及びデキサメタゾン併用時におけるアザセトロン塩酸塩(セロトーン® 静注液10mg)の薬物動態試験」
    坂田之訓、坂本慶、原弘光、入江伸、熊谷雄治、池田篤史、成橋真也、石川智弘、尾崎秀樹
    診療と新薬 第47巻 第12号(2010年12月)
●ウロダイナミクス関連
  • Effect of duloxetine on urethral resting pressure and on sphincter contractility in response to coughing and magnetic stimulation in healthy women. Yono M, Otani M, Ito K, Inoue Y, Furukawa K, Hori M, Tsuji S, Tanaka T, Sakata Y, Irie S., LUTS: lower urinary tract symptoms (2014), in press.
 
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