souseikai global clinical research center

Cold Pressor Test

The cold pressor test is an experimental pain model that has been widely used to produce and measure human pain in clinical studies using healthy subjects.

In an effort to contribute to the development of better pain medication, we have established a method of pain evaluation for young healthy Japanese subjects using the cold pressor test.

The cold pressor test is performed by immersing a subject's dominent hand in cold water (4℃).
Each subjects' pain threshold (time it takes for the subject to feel pain) pain tolerance (time until the subject is no longer able to bear the pain, removing their hand from the cold water), as well as visual analogue scale (VAS), Numerical Rating scale (NRS), and the McGill Pain Questionnaire are measured to evaluate pain.

Using this technique, we are able to assess the analgesic effects of various types of pain medications.